Acute generalized exanthematous pustulosis (AGEP) in Singapore

Results There were 20 cases of AGEP that were seen during the study period. Of which there are 8 males (40%) and 12 (females (60%) with a mean age of 60 years (Range : 24-85 years). In addition to extensive pinpoint pustules, other cutaneous features included facial edema, target-like lesions with rim of pustules and edema bulla. Common laboratory derangement included leukocytosis, eosinophilia, atypical lymphocytes and elevated C reactive protein. 25% and 30% of cases had liver or renal impairment respectively. The most common causative drugs were betalactam antibiotics, fluoroquinolones and anti-epileptic medications. The median latency from drug initiation to onset of rash was 5 days. 90% of cases resolved within 2 days. In-hospital mortality was 10%.